Endocrine Abstracts

Objective: The EarLy Surveillance for Autoimmune diabetes (ELSA) study is screening 20,000 children aged 3-13 years for type 1 diabetes through measurement of islet autoantibodies. Screening aims to prevent diabetic ketoacidosis at clinical onset of disease and identifies the population who could benefit from prevention trials. The ELSA-1 study aimed to explore the perspectives of parents and stakeholders on the relative benefits and limitations of screening i...

Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming to delay disease onset. Teplizumab is the first immunomodulatory agent licensed in the US to delay the onset of T1D by 3 years in individuals at risk; a licensing decision is awaited in the UK. The EarLy Surveill...

Section 1: Case history: A 46 year old man with Becker Muscular Dystrophy (BMD), was admitted with palpitations and shortness of breath. He had a past medial history of severe left ventricular dysfunction (LVSD) and cardiac arrhythmias, including atrial fibrillation (AF) treated with amiodarone, and an implantable cardiac defibrillator (ICD) for non-sustained ventricular tachycardia (VT). He had been treated with 3 months of prednisolone for suspected type 2 amiodarone induced...

Introduction: Hypercortisolaemia is characterised by an increased risk of cardiovascular disease (CVD), either through a direct action on the myocardium or by affecting traditional cardiovascular risk factors. The electrocardiogram (ECG) is the initial examination to assess the structural and functional characteristics of the myocardium.Aim of the study: To investigate whether the metabolic and cardiovascular features of Cushing’s disease (CD) are a...

Background: The Congenital adrenal Hyperplasia (CAH) Adult Study Executive (CaHASE) identified poor metabolic outcomes and reduced quality of life in CAH. CaHASE2 was recently established to examine the current status of CAH care. We surveyed clinical practice in the UK and Ireland, and awareness and use of the International CAH (I-CAH) Registry.Methods: We undertook an anonymised online survey targeting clinicians provi...

Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming for immunoprevention. The EarLy Surveillance for Autoimmune diabetes (ELSA) study is exploring feasibility and acceptability of UK paediatric general population screening.Methods:</...

Background: Sepsis is hallmarked by an immediate and sustained decrease in total-, HDL-, and LDL- cholesterol, associated with poor outcome and suggested to be a potential contributor to adrenal failure and muscle weakness in the critically ill. Although the underlying mechanisms are unclear, this sepsis-induced hypocholesterolemia has been postulated to be due to an increased conversion of cholesterol to cortisol. We hypothesized that hydrocortisone (HC) trea...

Introduction: TSH-stimulated serum thyroglobulin (Tg) is used as a sensitive marker for the detection of early recurrence or residual disease following treatment for differentiated thyroid cancer (DTC). However, stimulated Tg, using TSH or thyroid hormone withdrawal, is either costly or cumbersome for patients.Aim: To compare the performance of basal T4 suppressed, with stimulated Tg measurement, in the follow up of patients treated for DTC.</...

Background: Evaluating treatment (Tx) Response in NETs using CT/MRI scans can be difficult. Previous studies, including the E2211, have shown improved progression-free survival (PFS) but no significant difference in Rp as measured by RECIST 1.1 (R1.1) criteria. Therefore, it is difficult to determine Tx effectiveness with short-term imaging, further complicated by differences in imaging protocols and inter-reader variability. Incorporating tumor density, using smaller threshol...

Case history: A 59 year old woman presented to hospital with severe abdominal pain, diarrhoea and vomiting. Her past medical history included end stage renal failure of unknown cause, renal transplant with antithymocyte globulin (ATG) induction ten years prior, treated pulmonary tuberculosis, hypertension and new onset diabetes after transplant (NODAT).Investigations: A CT scan of the abdomen demonstrated an 85 x 74 x 96mm heterogenous mass arising from ...